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Juvenile nasopharyngeal angiofibroma (JNA) is a rare locally invasive neoplasm composed of cavernous vascular channels set in an abundant myxoid stroma of fibroblasts and myofibroblasts.1,2 The histological similarity to erectile tissue, the almost exclusive occurrence in pubescent males, and expression of multiple steroid receptors suggest that JNA growth is stimulated by male sex hormones.1,3
The frequency of JNA is significantly increased in male familial adenomatous polyposis (FAP) patients, suggesting that it may arise through alterations of the adenomatous polyposis coli (APC)/β-catenin gene pathway.4 This was supported by the high frequency of recurrent β-catenin gene mutations detected in sporadic JNA, but no APC mutations have thus far been found.5–7
We analysed the sequence of the APC gene and the presence of recurrent β-catenin mutations in matched blood and tumour …
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Conflict of interest: None declared.