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Recently, Karban and colleagues1 reported an association of a common NFKB1 gene polymorphism, −94ins/delATTG, with ulcerative colitis (UC) in a non-Hispanic, non-Jewish North American population. The deletion was significantly associated with disease in both family based and case control studies: in the combined case control cohort, the allele frequency of −94delATTG (D) was significantly increased in 350 non-Jewish UC cases (45.3%) compared with 802 non-Jewish controls (38.8%, p = 0.002). In a recessive model of inheritance, the homozygous (DD) genotype was significantly increased in UC cases (21.4%) compared with controls (14.8%) (p = 0.0043), giving an odds ratio of 1.57 for the DD genotype (95% confidence interval 1.14–2.16).
Nuclear factor κB (NFκB) is an important transcription factor implicated in the inflammatory response.2 The NFKB1gene, which encodes the p105/p50 subunit of the NFκB family of proteins, maps to chromosome 4q24, in a region showing linkage to inflammatory bowel disease3–5; a …
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Conflict of interest: None declared.