Article Text
Leading article
Colorectal cancer prognosis: is it all mutation, mutation, mutation?
Abstract
For the 500 000 new cases of colorectal cancer in the world each year, identification of patients with a worse prognosis and those who are more likely to respond to treatment is a challenge. There is an increasing body of evidence correlating genetic mutations with outcome in tumours derived from human colorectal cancer cohorts. K-ras, but not p53 or APC, mutations appear to be associated with poorer overall survival in colorectal cancer patients.
- K-ras, Kirsten-ras
- APC, adenomatous polyposis coli
- genome
- colorectal cancer
- mutation
- prognosis
- Kirsten-ras
- adenomatous polyposis coli
- p53
Statistics from Altmetric.com
Footnotes
-
Conflict of interest: None declared.