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Approximately 75% of gastric mucosa associated lymphoid tissue (MALT) lymphomas can be cured by Helicobacter pylori eradication.1 It would be very useful to identify, at the time of diagnosis, the 25% of cases of gastric MALT lymphoma that will not respond to H pylori eradication. In general, lymphomas at stage IIE or above do not respond to H pylori eradication.2–4 However, the prognostic value of staging in stage IE cases is very limited, although tumours that involve the muscularis propria or serosa (stage IE2) show a higher failure rate than those restricted to the mucosa and submucosa (stage IE1).2–4 Paradoxically, the majority of gastric MALT lymphomas at diagnosis are at stage IE but 20% of these cases will not respond to H pylori eradication.
In a previous study, we have examined the value of t(11;18)(q21;q21) in prediction of the response …
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Conflict of interest: None declared.