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Gut 55:1527-1528 doi:10.1136/gut.2006.100297
  • Letter

Association study of TNFSF15 polymorphisms in Japanese patients with inflammatory bowel disease

  1. Y Kakuta,
  2. Y Kinouchi,
  3. K Negoro,
  4. S Takahashi,
  5. T Shimosegawa
  1. Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
  1. Correspondence to:
    Dr Y Kakuta
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, Sendai, 980-8574, Japan; ykakuta{at}mail.tains.tohoku.ac.jp

    Tumour necrosis factor superfamily (TNFSF) 15 is a novel member of the TNFSF and its mRNA and protein expression is upregulated in inflammatory bowel disease (IBD), particularly in Crohn’s disease (CD).1,2 Recently, Yamazaki et al performed a large scale case control study using single nucleotide polymorphism (SNP) markers and reported that polymorphisms in TNFSF15 conferred susceptibility to CD in both Japanese and UK populations.3 They also suggested a potential association between a Caucasian ulcerative colitis (UC) cohort and TNFSF15, but this association was not studied in Japanese patients. To investigate this possible association between TNFSF15 and Japanese UC, and to replicate this association with CD in Japanese, we performed a case control association study in Japanese patients …