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Histological diagnosis of chronic pancreatitis has classically been limited to the study of surgical specimens. Histological features of chronic pancreatitis include loss of acinar cells, presence of an irregular interlobular fibrosis, infiltration of inflammatory cells, and relative conservation of intralobular ducts and islets.1 As pancreatic biopsies are rarely done in the context of chronic pancreatitis, histological characteristics of different stages of the disease are unknown. Endoscopic ultrasound (EUS) guided fine needle aspiration (FNA) has been proved to be a safe and useful method for tissue sampling of intramural and extramural gastrointestinal lesions, including those located in the pancreas.2,3 Cytological study of material obtained by FNA allows evaluation of cellular findings suggestive of malignancy, but not tissular features of chronic pancreatitis.4,5 We have recently modified …
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