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In a previous prospective study on the diagnostic value of serological markers in patients with indeterminate colitis (IC), we demonstrated that those who remained classified as IC during prospective follow up were more often negative for anti-Saccharomyces cerevisiae antibodies (ASCA) and atypical perinuclear antineutrophil cytoplasmic antibodies (pANCA) compared with patients with an eventual diagnosis of Crohn’s disease (CD) or ulcerative colitis (UC).1 New antibodies directed against luminal bacterial components have been reported in inflammatory bowel disease. Anti-OmpC IgA (directed against outer membrane porin C of E coli) and anti-I2 (directed against Pseudomonas fluorescens) have both been found in approximately 50% of CD patients2–4 and are both associated with ileal disease, increasing disease duration, and more severe disease that requires small bowel surgery.5,6
We investigated if anti-OmpC and anti-I2 were additive to ASCA and pANCA in the definitive diagnosis of patients who were included in our initial cohort of …
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