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  1. R Jover1,
  2. A Castells2,
  3. X Llor3,
  4. M Andreu4
  1. 1Gastroenterology Department, Hopital General Universitario de Alicante, Alicante, Spain
  2. 2Department of Gastroenterology, Institut de Malaties Digestives, Hospital Clínic, IDIBAPS, University of Barcelona, Barcelona, Spain
  3. 3Germans Trias i Pujol Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain
  4. 4Department of Gastroenterology, Hospital del Mar, Barcelona, Spain
  1. Correspondence to:
    R Jover
    Gastroenterology Department, Hospital General Universitario de Alicante, C/Pintor Baeza, sn 03010 Alicante, Spain; jover_rod{at}gva.es

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We thank Iacopetta and Watanabe for their interest in our paper (Gut 2006;55:1671–2). We do not agree, however, with their conclusions. There is important evidence in the recent literature that supports a relative lack of efficacy for 5-fluorouracil (5-FU) in patients with mismatch repair (MMR)-deficient tumours, with several studies reaching similar conclusions.1–4 In our study, we did not find major differences in patients with MMR-deficient tumours in survival or disease-free survival regarding adjuvant treatment, especially when we compared those results with the ones obtained in patients with MMR-proficient tumours. Although we acknowledge that we had only 53 patients with MMR-deficient tumours, our …

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