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Circulating ghrelin rapidly responds to food intake, being decreased by carbohydrates and fat1 and increased by proteins1 or amino acids.2 Leptin also affects energy expenditure. While ghrelin stimulates food intake,3 leptin induces satiety.4 It has therefore been postulated as an antagonist of ghrelin.4
The salivary glands are additional sources of both peptides.5,6 Determination of salivary values has been suggested as a non-invasive alternative to serum.7 We investigated the postprandial response of salivary ghrelin and leptin to determine whether this non-invasive application is useful in clinical practice.
Serum and saliva were obtained from healthy males (n = 11; 18–40 years; body mass index (BMI) 19–27 kg/m2), before and two hours after intake of 1 g/kg glucose (fig 1). Patients (n = 18, 9.9 (4.4) years, BMI 13–26.5 kg/m …
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