Article Text

PDF
Postprandial response of salivary ghrelin and leptin to carbohydrate uptake
  1. M Gröschl,
  2. H G Topf,
  3. M Rauh,
  4. M Kurzai,
  5. W Rascher,
  6. H Köhler
  1. Department of Paediatrics, University, Erlangen-Nürnberg, Germany
  1. Correspondence to:
    Dr M Gröschl
    Klinik für Kinder und Jugendliche, Loschgestrasse 15, 91054 Erlangen, Germany; michael.groeschl{at}kinder.imed.uni-erlangen.de

Statistics from Altmetric.com

Circulating ghrelin rapidly responds to food intake, being decreased by carbohydrates and fat1 and increased by proteins1 or amino acids.2 Leptin also affects energy expenditure. While ghrelin stimulates food intake,3 leptin induces satiety.4 It has therefore been postulated as an antagonist of ghrelin.4

The salivary glands are additional sources of both peptides.5,6 Determination of salivary values has been suggested as a non-invasive alternative to serum.7 We investigated the postprandial response of salivary ghrelin and leptin to determine whether this non-invasive application is useful in clinical practice.

Serum and saliva were obtained from healthy males (n = 11; 18–40 years; body mass index (BMI) 19–27 kg/m2), before and two hours after intake of 1 g/kg glucose (fig 1). Patients (n = 18, 9.9 (4.4) years, BMI 13–26.5 kg/m …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.