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The discovery in 2001 that three single nucleotide polymorphisms (SNPs) in the CARD15 gene are associated with Crohn’s disease is one of the most important advances in inflammatory bowel disease (IBD) research in recent years.1,2 This finding has led to further insights into disease pathogenesis,3 and subsequent genotype-phenotype studies have suggested that these SNPs are associated with an increased risk of terminal ileal and complicated disease behaviour.4 Interestingly, alleles of these CARD15 SNPs are known to vary significantly among ethnic subgroups,5 which may have important implications for the ethnic specific risk of Crohn’s disease. In this letter, we report CARD15 allele frequencies for the New Zealand (NZ) Maori population and discuss these …
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