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Does a lower insulin resistance affect antiviral therapy response in patients suffering from HCV related chronic hepatitis?
  1. G Tarantino,
  2. P Conca,
  3. M Ariello,
  4. M Mastrolia
  1. Department of Clinical and Experimental Medicine, Federico II University Medical School of Naples, Naples, Italy
  1. Correspondence to:
    Dr G Tarantino
    Department of Clinical and Experimental Medicine, Federico II University Medical School of Naples, Via S. Pansini 5 80131, Italy; tarantin{at}unina.it

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According to a recently published study (Gut 2005;54:1003–8), insulin resistance is a worsening factor in hepatitis C virus (HCV) related chronic hepatitis. There is much debate as to whether insulin resistance depends on hepatitis C virus, or vice versa, or whether it is an independent syndrome.

As insulin resistance is the link between obesity, metabolic alterations, and endothelial damage, it is a characteristic feature of the metabolic syndrome. Non-alcoholic steatohepatitis is a …

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