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Risk of subsequent development of gastric cancer in patients with previous gastric epithelial neoplasia
  1. T Aoi1,
  2. H Marusawa2,
  3. T Sato3,
  4. T Chiba4,
  5. M Maruyama5
  1. 1Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, and Department of Internal Medicine, St Luke’s International Hospital, Tokyo, Japan
  2. 2Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
  3. 3Department of Biostatistics, Graduate School of Medicine, Kyoto University, Kyoto, Japan
  4. 4Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
  5. 5Department of Internal Medicine, St Luke’s International Hospital, Tokyo, Japan
  1. Correspondence to:
    Dr T Chiba
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan; chiba{at}kuhp.kyoto-u.ac.jp

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The development of gastric epithelial neoplasia is closely linked to precursor conditions in the background mucosa.1–3 Recently, endoscopic mucosal resection (EMR) has become widely used for the treatment of gastric neoplasia,4 resulting in almost complete conservation of the patient’s stomach. To determine the risk of a second cancer in the stomach that once gave rise to epithelial neoplasia, we conducted a long term retrospective cohort study of 255 patients with primary gastric epithelial neoplasia who underwent curative resection by EMR between 1983 and 2002 at our hospital.

Characteristics of the subjects at the initial treatment are shown in table 1. Synchronous multiple neoplasias were confirmed in 19 (7.5 %) of the 255 subjects; 56 patients had adenomas and 199 had cancer. In the eight patients with both gastric cancer and adenoma, cancer was taken as the representative histology. In this study, we defined lesions classified as category 3 in the Vienna classification5 as “adenoma” and categories 4 and 5 as “cancer”.

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Table 1

 Characteristics of the …

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