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Infliximab as a treatment for systemic amyloidosis associated with Crohn’s disease
  1. M Iizuka,
  2. S Konno,
  3. Y Horie,
  4. H Itou,
  5. K Shindo,
  6. S Watanabe
  1. Department of Internal Medicine, Akita University School of Medicine, Akita, Japan
  1. Correspondence to:
    Dr M Iizuka
    Department of Internal Medicine, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan; maiizuka{at}doc.med.akita-u.ac.jp

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Systemic AA amyloidosis is a serious and potentially fatal complication of Crohn’s disease.1 This serious complication is associated with approximately 0.9–2.5% of patients with Crohn’s disease but renal failure due to renal amyloidosis is one of the most common causes of death for patients with Crohn’s disease.2 Although drugs such as azathioprine, colchicines, and dimethylsulphoxide are suggested to delay the progression of renal amyloidosis, the efficacy of these drugs on renal amyloidosis has not been fully elucidated.2 Infliximab is a chimeric anti-tumour necrosis factor α (TNF-α) monoclonal antibody. This drug has been proven …

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