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Gut 55:746 doi:10.1136/gut.2005.089136
  • Letter

Mannan binding lectin (MBL) gene polymorphisms are not associated with anti-Saccharomyces cerevisiae (ASCA) in patients with Crohn’s disease

  1. S Joossens1,
  2. M Pierik1,
  3. A Rector2,
  4. S Vermeire3,
  5. M V Ranst4,
  6. P Rutgeerts5,
  7. X Bossuyt6
  1. 1Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
  2. 2Laboratory of Clinical and Epidemiological Virology, University Hospital Gasthuisberg, Leuven, Belgium
  3. 3Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
  4. 4Laboratory of Clinical and Epidemiological Virology, University Hospital Gasthuisberg, Leuven, Belgium
  5. 5Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
  6. 6Laboratory of Medicine, University Hospital Gasthuisberg, Leuven, Belgium
  1. Correspondence to:
    Dr S Joossens
    Department of Gastroenterology, University Hospital, Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium; sofie.joossens{at}uz.kuleuven.ac.be

    Recently, an association between the presence of antibodies to Saccharomyces cerevisiae (ASCA) and mutations in exon 1 and the promoter region of the mannan binding lectin (MBL) gene was described in 58 patients with Crohn’s disease (CD).1 A possible link between ASCA and MBL mutations in patients with CD is plausible. MBL is a component of the innate immune system that can bind to S cerevisiae and the serum concentration of MBL …