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We read with great interest the review of gastrointestinal complications after pelvic radiotherapy by Andreyev (Gut 2005;54:1051–4). Andreyev emphasised the importance of fibrosis as the underlying cause for most gastrointestinal symptoms after radiotherapy and concluded that reversal or prevention of fibrosis could be highly profitable in the treatment of this complication, referring several antifibrotic agents such as liposomal Cu/Zn superoxide dismutase.1 However, there is another important target for the treatment …
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