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Association of the macrophage migration inhibitory factor gene polymorphisms with inflammatory bowel disease
  1. J Oliver1,
  2. A Márquez2,
  3. M Gómez-Garcia3,
  4. A Martinez4,
  5. J L Mendoza5,
  6. J R Vilchez6,
  7. M A López-Nevot6,
  8. A Piñero7,
  9. E G de la Concha8,
  10. A Nieto9,
  11. E Urcelay10,
  12. Dr J Martín11
  1. 1Instituto de Parasitología y Biomedicina López-Neyra, CSIC, Granada, Spain
  2. 2Servicio de Inmunología, Hospital Clínico San Carlos, Madrid, Spain
  3. 3Servicio de Digestivo, Hospital Virgen de las Nieves, Granada, Spain
  4. 4Servicio de Inmunología, Hospital Clínico San Carlos, Madrid, Spain
  5. 5Servicio de Digestivo, Hospital Clínico San Carlos, Madrid, Spain
  6. 6Servicio de Inmunología, Hospital Virgen de las Nieves, Granada, Spain
  7. 7Servicio de Digestivo, Hospital Puerta del Mar, Cádiz, Spain
  8. 8Servicio de Inmunología, Hospital Clínico San Carlos, Madrid, Spain
  9. 9Servicio de Inmunología, Hospital Puerta del Mar, Cádiz, Spain
  10. 10Servicio de Inmunología, Hospital Clínico San Carlos, Madrid, Spain
  11. 11Instituto de Parasitología y Biomedicina López-Neyra, CSIC, Granada, Spain
  1. Correspondence to:
    Dr J Martín
    Instituto de Parasitología y Biomedicina “López-Neyra”, CSIC, Parque Tecnológico de Ciencias de la Salud, Avenida del Conocimiento s/n 18100-Armilla, Granada, Spain; martin{at}ipb.csic.es

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Macrophage migration inhibitory factor (MIF), an immunoregulatory cytokine that has pro-inflammatory, hormonal and enzymatic activities, has been found to be markedly increased in the serum of patients with inflammatory bowel disease (IBD).1,2 MIF-deficient mice failed to develop disease1 and blockage with anti-MIF antibody reduced disease activity.1,2 Finally, functional polymorphisms of the human MIF gene have been associated with increased susceptibility to inflammatory and autoimmune diseases.3 These findings prompted us to investigate the potential association of the functional MIF −173G/C and −794 (CATT)n gene variants with the susceptibility and clinical expression of IBD.

We studied a case–control cohort (cohort 1) comprising 336 patients with Crohn’s disease and 287 patients with ulcerative colitis from south Spain and 361 controls from the same area. An additional cohort (cohort 2) was analysed, comprising 325 patients with Crohn’s disease, 347 patients with ulcerative colitis and 526 controls from Madrid. Table 1 shows the clinical characteristics …

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