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Mannan-binding lectin (MBL) is a member of the collectin family and is an important component of the innate immune response. Three different MBL alleles in coding exon 1 (point mutations in codons 52, 54 and 57) result in low serum levels of MBL.1 Earlier, we described cellular and humoral immune reactivity of a subgroup of patients with Crohn’s disease to mannans, a cell wall antigen of yeasts.2 The humoral immune response in these patients is commonly known as antibodies to Saccharomyces cerevisiae (ASCA). In a previous paper, we found considerably more patients with Crohn’s disease with low MBL serum levels to be ASCA positive than in the subgroup with high MBL levels. The homozygotic or compound heterozygotic mutations in the exon were associated with the development of ASCA in patients with Crohn’s disease.3
This is in contrast with the data reported in this journal by …
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