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The IL23 axis plays a key role in the pathogenesis of IBD

Abstract

Exciting new results from a genetic study in humans and functional studies in mice have pinpointed interleukin 23 (IL23) and its receptor as a key pathway in the pathogenesis of inflammatory bowel disease (IBD). These findings reveal a hitherto unappreciated role for the IL23 axis in intestinal inflammation and may open new avenues for development of therapeutic strategies in IBD.

  • DC, dendritic cell
  • IBD, irritable bowel disease
  • IFNγ, interferon γ
  • IL, interleukin
  • IL23R, interleukin 23 receptor
  • SNP, single-nucleotide polymorphism
  • TGFβ, transforming growth factor β
  • Th, T helper
  • TNFα, tumour necrosis factor α

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Footnotes

  • Competing interests: None.

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