Exciting new results from a genetic study in humans and functional studies in mice have pinpointed interleukin 23 (IL23) and its receptor as a key pathway in the pathogenesis of inflammatory bowel disease (IBD). These findings reveal a hitherto unappreciated role for the IL23 axis in intestinal inflammation and may open new avenues for development of therapeutic strategies in IBD.
- DC, dendritic cell
- IBD, irritable bowel disease
- IFNγ, interferon γ
- IL, interleukin
- IL23R, interleukin 23 receptor
- SNP, single-nucleotide polymorphism
- TGFβ, transforming growth factor β
- Th, T helper
- TNFα, tumour necrosis factor α
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Competing interests: None.
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