Gut 56:1333-1336 doi:10.1136/gut.2006.115402
  • Leading article

The IL23 axis plays a key role in the pathogenesis of IBD

  1. Dermot McGovern1,
  2. Fiona Powrie2
  1. 1Imperial College, London, Hammersmith Hospital Campus, Du Cane Road, London, UK
  2. 2Sir William Dunn School of Pathology, University of Oxford, South Parks Rd, Oxford, UK
  1. Correspondence to:
    Dermot McGovern
    Imperial College, London, Hammersmith Hospital Campus Du Cane Road, London W12 0HS, UK; dermotmcgovern{at}
  • Accepted 11 April 2007
  • Revised 27 March 2007


Exciting new results from a genetic study in humans and functional studies in mice have pinpointed interleukin 23 (IL23) and its receptor as a key pathway in the pathogenesis of inflammatory bowel disease (IBD). These findings reveal a hitherto unappreciated role for the IL23 axis in intestinal inflammation and may open new avenues for development of therapeutic strategies in IBD.


  • Competing interests: None.