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Recent advances in clinical practice
Advances in counselling and surveillance of patients at risk for pancreatic cancer
  1. Randall E Brand1,
  2. Markus M Lerch2,
  3. Wendy S Rubinstein1,
  4. John P Neoptolemos3,
  5. David C Whitcomb4,
  6. Ralph H Hruban5,
  7. Teresa A Brentnall6,
  8. Henry T Lynch7,
  9. Marcia I Canto5,
  10. Participants of the Fourth International Symposium of Inherited Diseases of the Pancreas
  1. 1Evanston Northwestern Healthcare, Evanston, Illinois, USA
  2. 2Ernst-Moritz-Arndt-Universitat, Greifswald, Germany
  3. 3Liverpool University, Liverpool, UK
  4. 4University of Pittsburgh, Pittsburgh, Pennsylvania, USA
  5. 5The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
  6. 6University of Washington, Seattle, Washington, USA
  7. 7Creighton University, Omaha, Nebraska, USA
  1. Correspondence to:
    Randall E Brand
    MD, 2100 Pfingsten Road Suite B230, Glenview, Illinois 60026, USA; rbrand{at}enh.org

Abstract

Even with significant advances in imaging and our understanding of pancreatic cancer genetics, the survival rates for pancreatic cancer remain quite dismal. Although still at an early stage, there are efforts in place to develop surveillance and prevention strategies for people at high risk for pancreatic cancer. This comprehensive review article summarises the predispositions that put people at a high risk of developing pancreatic cancer and the current status in the counselling and surveillance of these people using not only available medical literature, but also incorporating international expert opinion.

  • ASCO, American Society of Clinical Oncology
  • BMI, body mass index
  • CT, computed tomography
  • ERCP, endoscopic retrograde cholangiopancreatography
  • ESPAC, European Study Group for Pancreatic Cancer
  • EUS, endoscopic ultrasound
  • FAMMM, familial atypical multiple mole melanoma
  • HBOC, hereditary breast and ovarian cancer syndrome
  • IPMN, intraductal papillary mucinous neoplasm
  • MRI, magnetic resonance imaging
  • PanIN, pancreatic intraepithelial neoplasm
  • PC, pancreatic cancer
  • PJS, Peutz–Jeghers syndrome
  • pancreatic cancer
  • recommendations
  • prevention
  • genetic counselling
  • genetic testing
  • risk factors

https://doi.org/10.1136/gut.2006.108456

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    Footnotes

    • ↵i By REB, WSR, MML, JPN, and DCW.