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Bone marrow stem cells and liver disease
  1. Andre Castro Lyra1,
  2. Milena Botelho Pereira Soares2,
  3. Ricardo Ribeiro dos Santos2,
  4. Luiz Guilherme Costa Lyra3
  1. 1
    Hospital Sao Rafael, Federal University of Bahia, Salvador, Bahia, Brazil
  2. 2
    Hospital Sao Rafael, Fundacao Oswaldo Cruz, Salvador, Bahia, Brazil
  3. 3
    Hospital Sao Rafael, Federal University of Bahia, Salvador, Bahia, Brazil
  1. Dr A C Lyra, Rua Sócrates Guanaes Gomes 84/401, Salvador, Bahia, Brazil 40 296 720; aclyra{at}atarde.com.br

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The review article by Kallies et al focuses on the various relationships between bone marrow stem cells (BMSC) and liver diseases (Gut 2007;56:716–24). It discusses experimental studies with animal models and critically examines the possible role of BMSC in liver repair through the delivery of growth factors, fibrosis resolution and new blood vessel formation.

In addition, the authors examine the development of BMSC treatment of liver diseases and describe three uncontrolled phase 1 clinical trials in humans published up to December …

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