Article Text

PDF
The pattern of cytokine expression determines the degree of mucosal damage
  1. A J León1,
  2. E Gómez1,
  3. J A Garrote1,2,
  4. E Arranz3
  1. 1Departament of Paediatrics and Immunology and Institute of Biology and Molecular Genetics (IBGM), Universidad de Valladolid, Valladolid, Spain
  2. 2Research Unit, Hospital Clínico Universitario, Valladolid, Spain
  3. 3Departament of Paediatrics and Immunology and Institute of Biology and Molecular Genetics (IBGM), Universidad de Valladolid, Valladolid, Spain
  1. Correspondence to:
    Dr E Arranz
    Department of Paediatrics and Immunology, and Institute of Biology and Molecular Genetics, University of Valladolid, C/Ramón y Cajal 7, 47005-Valladolid, Spain; earranz{at}med.uva.es

Statistics from Altmetric.com

It is widely accepted that both qualitative and quantitative differences in cytokine expression determine the extent of mucosal damage in different intestinal pathologies.1 However, few comparative analyses of these conditions have been published to date.

We analysed mRNA expression of several cytokines and effector molecules in intestinal biopsies by real time polymerase chain reaction (summary of study groups and results are shown in table 1). These included samples from healthy controls (duodenal biopsies from patients suspected of having an intestinal pathology, later ruled out), non-specific small bowel inflammation (mild histological changes in the biopsy consisting of a non-specific …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.