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Functional polymorphisms in the promoters of MMP-1, MMP-2, MMP-3, MMP-9, MMP-12 and MMP-13 are not associated with hepatocellular carcinoma risk
  1. Yun Zhai1,
  2. Wei Qiu1,
  3. Xiao-Jia Dong2,
  4. Xiu-Mei Zhang3,
  5. Wei-Min Xie4,
  6. Hong-Xing Zhang5,
  7. Xiao-Yan Yuan5,
  8. Gang-Qiao Zhou5,
  9. Fu-Chu He5
  1. 1Beijing Proteome Research Center, Beijing, China
  2. 2Chinese National Human Genome Center at Beijing, Beijing, China
  3. 3Department of Functional Genomics, Beijing Proteome Research Center, Beijing, China
  4. 4Cancer Institute of Guangxi, Nanning, China
  5. 5Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine, Beijing, China; Department of Functional Genomics, Beijing Proteome Research Center, Beijing, China
  1. Correspondence to:
    Dr F-C He
    Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing, 100850, China; hefc{at}nic.bmi.ac.cn; or Dr G-Q Zhou, the State Key Laboratory of Proteomics, Beijing Institute of Radiation Medicine, Beijing Proteome Research Center, 27 Taiping Road, Beijing, 100850, China; zhougq{at}chgb.org.cn

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The matrix metalloproteinases (MMPs) play an important role in several steps of cancer development by regulating cancer-cell growth, differentiation, apoptosis, invasion, metastasis, angiogenesis and immune surveillance.1 Several polymorphisms in the promoters of a number of MMP genes, which are thought to affect the respective MMP production in an allele-specific manner, have been well characterised.2–4 There is increasing evidence indicating that these functional polymorphisms may contribute to interindividual differences in susceptibility to a wide spectrum of cancers.2–7 The role of the MMPs polymorphisms in hepatocellular carcinoma (HCC), however, has never been specifically investigated. As MMPs are plausible HCC candidate genes, we sought to examine whether the MMP polymorphisms have any bearing on the risk of HCC. Among the candidate polymorphisms, we focused on seven in the promoters of six MMP genes. These polymorphisms were MMP-1 -1607 1G/2G (rs1799750), MMP-2 C-1306T (rs243865) and C-735T (rs2285053), MMP-3 -1612 5A/6A (rs3025058), MMP-9 C-1562T (rs3918242), MMP-12 G-82A (rs2276109), and MMP-13 G-77A (rs17860523), respectively.2–7

We genotyped these seven polymorphisms in 434 incident patients with HCC and 480 controls …

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