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It has always been a controversial subject whether patients with functional constipation have a higher risk of developing colorectal cancer. Watanabe et al1 showed an increase in relative risk (RR) 1.31 of colorectal cancer in those with constipation.1 Roberts et al2 showed an association with >twofold risk of colon cancer (OR 2.36) adjusted for age, race, sex and relevant confounders.2 On the other hand, both studies by Dukas et al3 and Kune et al,4 after adjusting for age, sex and other risk factors showed no increase in risk.
Colorectal cancer develops through the adenoma–carcinoma sequence.5 Thus, we aimed to compare the prevalence of colorectal adenomas in patients with long-standing functional constipation to an age, sex and …
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