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Interleukin1β (IL1β) is upregulated in the presence of Helicobacter pylori infection.1 IL1β polymorphisms with T/T and T/C genotypes enhance IL1β production, and are associated with an increased risk of H pylori-induced hypochlorhydria2 and gastric cancer.3 The relationship between H pylori and CpG island methylation has been repeatedly reported.4–6 It has been reported that IL1β can modulate CpG island methylation through activation of DNA methyltransferase and hence repress gene expression.7 We therefore hypothesised that patients with H pylori infection and IL1 polymorphism, by the production of IL1β, are predisposed to gastric cancer development through the CpG island methylation pathway.
We obtained surgical specimens and their corresponding peripheral blood from 98 consecutive patients with gastric cancer admitted to Queen Mary Hospital, Hong Kong. This study was approved by the ethics committee. The …
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