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Association between Helicobacter pylori infection and interleukin 1β polymorphism predispose to CpG island methylation in gastric cancer
  1. Annie On On Chan1,
  2. Kent-Man Chu2,
  3. Camy Huang3,
  4. Kwok Fai Lam3,
  5. Suet Yi Leung4,
  6. Yun Wei Sun5,
  7. Samuel Ko6,
  8. Harry H Xia7,
  9. Chi Hin Cho8,
  10. Wai Mo Hui8,
  11. Shiu Kum Lam8,
  12. Asif Rashid9
  1. 1Department of Medicine, The University of Hong Kong, Hong Kong
  2. 2Department of Surgery, Statistics & Actuarial Science, The University of Hong Kong, Hong Kong
  3. 3Department of Medicine, The University of Hong Kong, Hong Kong
  4. 4Department of Pathology, The University of Hong Kong, Hong Kong
  5. 5Department of Medicine, The University of Hong Kong, Hong Kong
  6. 6Department of Surgery, Statistics & Actuarial Science, The University of Hong Kong, Hong Kong
  7. 7Department of Medicine, The University of Hong Kong, Hong Kong
  8. 8Department of Medicine, The University of Hong Kong, Hong Kong
  9. 9Department of Pathology, MD Anderson Cancer Center, TX, USA
  1. Correspondence to:
    Dr A On On Chan
    Department of Medicine, Division of Gastroenterology and Hepatology, University of Hong Kong, China;aoochan{at}hku.hk

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Interleukin1β (IL1β) is upregulated in the presence of Helicobacter pylori infection.1 IL1β polymorphisms with T/T and T/C genotypes enhance IL1β production, and are associated with an increased risk of H pylori-induced hypochlorhydria2 and gastric cancer.3 The relationship between H pylori and CpG island methylation has been repeatedly reported.4–6 It has been reported that IL1β can modulate CpG island methylation through activation of DNA methyltransferase and hence repress gene expression.7 We therefore hypothesised that patients with H pylori infection and IL1 polymorphism, by the production of IL1β, are predisposed to gastric cancer development through the CpG island methylation pathway.

We obtained surgical specimens and their corresponding peripheral blood from 98 consecutive patients with gastric cancer admitted to Queen Mary Hospital, Hong Kong. This study was approved by the ethics committee. The …

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