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Clostridium difficile-associated diarrhoea: bovine anti-Clostridium difficile whey protein to help aid the prevention of relapses
  1. Sandra C Numan1,
  2. Peter Veldkamp2,
  3. Ed J Kuijper3,
  4. Renate J van den Berg3,
  5. Jaap T van Dissel4
  1. 1Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
  2. 2Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
  3. 3Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
  4. 4Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
  1. Correspondence to:
    Professor J T van Dissel
    Department of Infectious Diseases, C5-P, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands; j.t.van_dissel{at}lumc.nl

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Antibiotic treatment can usually help in symptomatic recovery in Clostridium difficile-associated diarrhoea (CDAD), but recurrent episodes of diarrhoea remain a major problem.1–4 Besides increasing the dose or extending the course of antibiotics, and using alternating or pulsed regimens, there are no effective alternatives to prevent relapses.5 Previously, we reported on anti-Clostridium difficile whey protein concentrate (anti-CD-WPC) made from the milk of cows immunised against C difficile and its toxins. Anti-CD-WPC is prepared using standard techniques used in the milk industry, and contains a high concentration of sIgA directed against C difficile and its toxins. It neutralises the cytotoxicity of C difficile toxins in vitro and protects hamsters against otherwise lethal C difficile-associated cecitis.6

The aim of this study was to assess the preliminary efficacy of anti-CD-WPC in aiding the prevention of relapses in patients with CDAD confirmed by positive faecal C difficile toxin assay and …

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