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Magnifying videoendoscopic findings of Peyer’s patches in the terminal ileum of Crohn’s disease
  1. Saburo Shikuwa1,*,
  2. Hajime Isomoto2,*,
  3. Yohei Mizuta2,
  4. Takashi Suematsu3,
  5. Masahiro Ito4,
  6. Shigeru Kohno5
  1. 1Department of Internal Medicine, National Nagasaki Medical Center, Omura, Nagasaki, Japan
  2. 2Second Department of Internal Medicine, Nagasaki University School of Medicine, Sakamoto, Nagasaki, Japan
  3. 3Central Electron Microscope Laboratory, Graduate School of Biomedical Sciences, Nagasaki University, Sakamoto, Nagasaki, Japan
  4. 4Department of Pathology, National Nagasaki Medical Center, Omura, Nagasaki, Japan
  5. 5Second Department of Internal Medicine, Nagasaki University School of Medicine, Sakamoto, Nagasaki, Japan
  1. Correspondence to:
    Dr H Isomoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 85-8562, Japan; hajimei2002{at}yahoo.co.jp

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It has been reported that Crohn’s disease initially occurs as tiny aphthoid lesions at the sites of lymphoid follicles in the gastrointestinal tract.1–3 The follicle-associated epithelium (FAE) of the gut-associated lymphoid tissues such as Peyer’s patches (PPs)3,4 is a single layer of epithelial cells covering each follicle and forms a dome between the surrounding villi.3,4 Endoscopic observation of PPs in patients with Crohn’s disease has rarely been performed in clinical settings.1–3,5,6

A total of seven patients with active Crohn’s disease and 19 age- and sex-matched healthy controls were enrolled. Chromoendoscopy was carried out with crystal violet and/or indigo carmine to identify PPs. The FAE on the domes of PPs was examined by magnifying endoscopy. The macroscopic appearance of PPs was classified into two categories, a nodular or convolute elevation pattern (E type, fig …

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