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Ischaemia–reperfusion injury in non-alcoholic steatohepatitis (NASH) liver: a tough problem to cope with
  1. C Xu,
  2. C Yu,
  3. Y Li
  1. Department of Gastroenterology, the First Affiliated Hospital, College of Medicine Zhejiang University, Hangzhou, China
  1. Dr Youming Li, Department of Gastroenterology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China; zlym{at}zju.edu.cn

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We were most interested to read the recent report by Serviddio and colleagues (Gut 2008;57:957–65). This work not only showed that upregulation of uncoupling protein-2 was a reason for progression of non-alcoholic steatohepatitis (NASH) from simple steatosis, but also gave an explanation for why NASH liver was especially vulnerable to ischaemia–reperfusion injury.

NASH is a common liver disease that is estimated to affect nearly 1% of the population. A growing body of evidences shows that NASH …

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