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The role of NF-κB activation in the pathogenesis of acute pancreatitis
  1. Z Rakonczay Jr1,
  2. P Hegyi1,
  3. T Takács1,
  4. J McCarroll2,
  5. A K Saluja3
  1. 1
    First Department of Medicine, University of Szeged, Szeged, Hungary
  2. 2
    Children’s Cancer Institute Australia for Medical Research, Sydney, NSW, Australia
  3. 3
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
  1. Dr Zoltán Rakonczay, First Department of Medicine, University of Szeged, H-6701 Szeged, P.O. Box: 427, Hungary; raz{at}in1st.szote.u-szeged.hu

Abstract

Acute pancreatitis is an inflammatory disease of the pancreas which, in its most severe form, is associated with multi-organ failure and death. Recently, signalling molecules and pathways which are responsible for the initiation and progression of this disease have been under intense scrutiny. One important signalling molecule, nuclear factor κB (NF-κB), has been shown to play a critical role in the development of acute pancreatitis. NF-κB is a nuclear transcription factor responsible for regulating the transcription of a wide variety of genes involved in immunity and inflammation. Many of these genes have been implicated as central players in the development and progression of acute pancreatitis. This review discusses recent advances in the investigation of pancreatic and extrapancreatic (lungs, liver, monocytes and macrophages, and endothelial cells) NF-κB activation as it relates to acute pancreatitis.

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Footnotes

  • Funding: This work was supported by NIH grants (DK-58694 and CA-124723 to AKS) and the Hungarian Scientific Research Fund (K60406 to TT and PF63951 to ZR), Hungarian Academy of Sciences (BO 00276/04 to PH and BO 00218/06 to ZR). JM was supported by a University of New South Wales (Faculty of Medicine) postdoctoral fellowship and ZR by The Physiological Society Junior Fellowship.

  • Competing interests: None.

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