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Dysbiosis in inflammatory bowel disease: a role for bacteriophages?
  1. P Lepage1,
  2. J Colombet2,
  3. P Marteau3,
  4. T Sime-Ngando2,
  5. J Doré1,
  6. M Leclerc1
  1. 1
    Unité d’Ecologie et de Physiologie du Système Digestif, INRA, Domaine de Vilvert, Jouy en Josas cedex, France
  2. 2
    Laboratoire de Biologie des Protistes, UMR CNRS 6023, Université Blaise Pascal, Aubière cedex, France
  3. 3
    AP-HP, Hôpital Lariboisière, 2 rue A. Paré, Paris, France
  1. Dr M Leclerc, Unité d’Ecologie et de Physiologie du Sytème Digestif, INRA, Bat 405, Domaine de Vilvert 78350 Jouy en Josas, France; marion.leclerc{at}jouy.inra.fr

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Intestinal bacteria have been implicated in the initiation and amplification of inflammatory bowel disease (IBD). The dysbiosis theory, reviewed by Tamboli et al (Gut 2004;53:1), is that an imbalance between putative “harmful” versus “protective” bacterial species may promote chronic intestinal inflammation. Although several studies published so far support this hypothesis, the most vexing question posed by Tamboli et al remains “what is the origin of dysbiosis?”. Bacteriophages outnumber bacteria by a factor of 10 in many natural ecosystems, exert a strong influence on bacterial diversity and population structure, and are probably involved in dysbiosis by destabilising bacterial communities.1 They could be involved indirectly through gene transfer and genome reorganisation within the bacterial population or directly as …

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