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Differential relationships between basal and post-load insulin resistance indices and hepatic fibrosis in chronic hepatitis C and in non-alcoholic fatty liver disease
  1. Giovanni Targher,
  2. Giacomo Zoppini,
  3. Michele Muggeo
  1. Section of Endocrinology, Department of Biomedical and Surgical Sciences, University Hospital, Verona, Italy
  1. Dr Giovanni Targher, Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Ospedale Civile Maggiore, Piazzale Stefani, 1, 37126 Verona, Italy; giovanni.targher{at}univr.it

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We read with interest the recent article by Svegliati-Baroni et al (Gut 2007;56:1296–301) regarding the differential relationships between different indices of insulin resistance and the severity of hepatic fibrosis in patients with non-alcoholic fatty liver disease (NAFLD) or chronic hepatitis C (CHC) with various degrees of glucose tolerance.

Notably, they found that post-load insulin resistance (by the oral glucose sensitivity index, OGIS) was independently associated with advanced fibrosis in both NAFLD and CHC, whereas the degree of basal insulin resistance (by the homeostasis model assessment, HOMA) was not. They conclude that OGIS index is an easy and reliable tool to identify patients with insulin resistance-associated hepatic fibrosis, and should be part of the general screening in these patients.

OGIS requires glucose …

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