Gut 57:561-567 doi:10.1136/gut.2007.133462
  • Leading article

Does Helicobacter pylori protect against asthma and allergy?

  1. Joan Reibman1,4
  1. 1 Department of Medicine, New York University School of Medicine, New York, USA
  2. 2 Department of Microbiology, New York University School of Medicine, New York, USA
  3. 3 Medical Service, New York Harbor Veterans Affairs, Medical Center, New York, USA
  4. 4 Department of Environmental Medicine, New York University School of Medicine, New York, USA
  1. Dr Martin J Blaser, Department of Medicine, 550 First Avenue OBV A606, New York, NY 10016, USA; martin.blaser{at}
  • Revised 4 December 2007
  • Accepted 11 December 2007
  • Published Online First 14 January 2008

The microbes that persistently colonise their vertebrate hosts are not accidental.1 Although highly numerous and diverse, there is specificity by site and substantial conservation between individuals. The genus Helicobacter includes spiral, highly motile, urease-positive, Gram-negative bacteria that colonise the stomach in many mammals. Each mammal has one or more dominant Helicobacter species and they are highly, if not exclusively, host species-specific.2 Such observations are consistent with the hypothesis that when ancestral mammals diverged from reptiles about 150 million years ago, they contained ancestral helicobacters, which then diverged as their hosts changed. According to this hypothesis, helicobacters represent ancestral biota (flora) in the mammalian stomach. The human-adapted strain is H pylori,3 which has not been reproducibly observed in any animals other than humans and other primates.3

Although we can not reliably estimate how long H pylori has been in the human stomach, its ancestors may have been present when our humanoid ancestors diverged from other primates about four million years ago. Consistent with this view are results from phylogeographic studies; strong and consistent evidence indicates that our ancestors already were carrying gastric H pylori when a group that ultimately populated much of the world last left Africa, more than 58 000 years ago.4 In any case, H pylori has been colonising the stomach of humans since at least Paleolithic times.

In this paper, we examine the evidence concerning the relationship of this ancient member of the human microbiota, and particularly its absence, with the recent and on-going epidemic of asthma and related allergic disorders. We discuss the possibility that gastric H pylori colonisation protects against these disorders and that its disappearance has fuelled their rise.


H pylori is acquired, and may be detected, in early childhood usually after the first year of life.5 Transmission is …

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