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Association of DLG5 variants with gluten-sensitive enteropathy
  1. E A Festen1,2,
  2. A Zhernakova3,
  3. C Wijmenga1,
  4. R K Weersma2
  1. 1
    Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
  2. 2
    Department of Gastroenterology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
  3. 3
    Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, The Netherlands
  1. Dr R K Weersma, Department of Gastroenterology, University Medical Centre Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands; R.K.Weersma{at}int.umcg.nl

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Both gluten-sensitive enteropathy (GSE) and inflammatory bowel diseases (IBDs) are characterised by inflammation of the intestinal mucosa and enhanced intestinal epithelial permeability. Previous studies have identified shared susceptibility genes for IBD and GSE. Myosin IXB, first identified as associated with GSE, was also proven to be associated with ulcerative colitis (UC).1 We would like to respond to the recent study performed by Wapenaar et al that identified two tight-junction genes, PARD3 and MAGI2, to be associated with both GSE and UC (Gut 2008;57:438). We have also found IBD-associated genetic variants in DLG5 to be associated with GSE.2 DLG5 is, like Myosin IXB, PARD3 and MAGI2, involved in maintaining the epithelial integrity, which makes it a suitable candidate gene for …

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