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Gut 57:1065-1072 doi:10.1136/gut.2007.145839
  • Helicobacter pylori

Correlation of T cell response and bacterial clearance in human volunteers challenged with Helicobacter pylori revealed by randomised controlled vaccination with Ty21a-based Salmonella vaccines

Table 2 Effects of vaccination on H pylori infection (second study)
Volunteer
Vaccine Ty21a control
8 13 18 23 29 71 77 81 90 96 98 101 102 103 104 108 121 125 127 129 132
Test*
H pylori culture + + – – + + + + – + + + + + – + – + + – +
RUT + + – + + + – + – – + + + + – – + + + + –
UBT + + – + + + + + – + + + + + – + + + + + –
H pylori histology + + + + + + + + + + + + + + – + + + + + –
Score 4 4 1 3 4 4 3 4 1 3 4 4 4 4 0 3 3 4 4 3 1
Vaccine Ty21a(pUreA/B)
Volunteer 5 12 16 39 48 70 72 78 87 99 106 119
Test
H pylori culture + + + + + + – + + + + +
RUT + + – + – + – + + – + +
UBT + + – + – + – + + + + +
H pylori histology + + – + + + + + + + – +
Score 4 4 1 4 2 4 1 4 4 3 3 4
Vaccine Ty21a(pHP0231)
Volunteer 14 19 35 43 46 60 66 73 75 91 107 117
Test
H pylori culture + + + + + + + + + + – +
RUT + + + + + + + + + + – +
UBT + + + + + + + + + + – +
H pylori histology + + + + + + + + + + – +
Score 4 4 4 4 4 4 4 4 4 4 0 4

  • *For definition of tests and score see the footnotes of table 1.

  • RUT, rapid urease test; UBT, [13C]urea breath test.

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