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Bacterial translocation and cardiovascular complications of cirrhosis
  1. U Thalheimer1,
  2. A K Burroughs2
  1. 1
    Dipartimento di Scienze Biomediche e Chirurgiche, Universitá di Verona, Verona, Italy
  2. 2
    The Sheila Sherlock Hepatobiliarypancreatic and Liver Transplantation Unit, Royal Free Hospital, London, UK
  1. Professor A K Burroughs, Liver Transplant Unit, The Royal Free Hospital, Hampstead, London NW3 2QG, UK; andrew.burroughs{at}royalfree.nhs.uk

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We read with interest the recent review on cardiovascular complications of cirrhosis by Møller and Henriksen (Gut 2008;57:268).

We would like to add to their overview what we believe to be one of the major contributors to cardiovascular derangement in cirrhosis—that is, bacterial translocation,1 as this was not mentioned by them.

Bacterial translocation leads to the presence of bacteria, endotoxins and cytokines in the systemic circulation, thus enhancing nitric oxide production.2 …

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    S Møller J H Henriksen