Article Text

PDF
Clostridium difficile infection and inflammatory bowel disease: a marker for disease extent?
  1. N Powell1,
  2. S E Jung2,
  3. B Krishnan2
  1. 1
    Imperial College Healthcare NHS Trust, Gastroenterology Department, Hammersmith Hospital Campus, London, UK
  2. 2
    Lister Hospital, Stevenage, UK
  1. Dr Nick Powell, Imperial College Healthcare NHS Trust, Gastroenterology Department, Hammersmith Hospital Campus, Du Cane Road, London W12 0HS, UK; nick.powell{at}nhs.net

Statistics from Altmetric.com

The article by Ananthakrishnan et al (Gut 2008;57:205–10) has suggested that there is increased morbidity and mortality in hospitalised patients with inflammatory bowel disease (IBD) who are concomitantly infected with Clostridium difficile compared with hospitalised IBD patients without infection. Such large epidemiological studies are powerful tools for identifying statistically significant associations, but must be tempered with caution when they attempt to explain causality. From the data presented we do not believe that it is possible to conclude that C difficile infection confers a greater risk of death in hospitalised patients with IBD. Importantly, there is no information regarding disease extent in the “infected” and “uninfected” IBD populations. It is plausible that disease extent, particularly …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles

  • Letter
    A N Ananthakrishnan E L McGinley D G Binion