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I read with great interest the article by Newton et al (Gut 2008;57:807–13) concerning fatigue in patients with non-alcoholic fatty liver disease (NAFLD). The authors enrolled 156 consecutive patients with histologically proven NAFLD in whom fatigue, depression, daytime somnolence, and health-related quality of life were assessed by means of validated questionnaires. Physical activity was also evaluated by accelerometry and results were compared to those of age-, sex-, and body mass index-matched healthy controls as well as patients with primary biliary cirrhosis. Fatigue was found to …
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