Table 5
Follow-up liver biopsy (n = 5)
| Patient no | Interval between first and last liver biopsy (months) | Date of liver biopsy (month/date/year) | Steatosis grade | Lobular inflammation grade | Fibrosis stage | Reason to repeat the liver biopsy |
| 1 | 33 | First biopsy (3/1993) | Moderate | Mild | 1 | – |
| Second biopsy (12/1995) | Moderate | Mild | 1 | Follow-up before ursodeoxycholic acid prescribed | ||
| 2 | 57 | First biopsy (7/1999) | Mild | Mild | 0 | – |
| Second biopsy (2/2001) | Moderate | Mild | 1 | Worsening of ALT levels | ||
| Last biopsy (4/2004) | Severe | Mild | 4 | Liver biopsy performed for persistently elevated ALT and done during laparoscopic cholecystectomy | ||
| 3 | 82 | First biopsy (12/1996) | Mild | Mild | 0 | – |
| Second biopsy (4/1999) | Moderate | Mild | 1 | Persistent abnormal liver tests | ||
| Last biopsy (11/2002) | Moderate | Moderate | 3 | Liver biopsy performed for persistently elevated liver enzymes and done during bariatric surgery | ||
| 4 | 28 | First biopsy (8/1990) | Moderate | Mild | 0 | – |
| Second biopsy (2/1991) | Moderate | Mild | 0 | Persistent abnormal liver tests | ||
| Third biopsy (12/1992) | Moderate | Mild | 1 | Follow-up before starting treatment with ursodeoxycholic acid | ||
| 5 | 7 | First biopsy (14 Oct 1998) | Mild | 0 | 0 | – |
| Second biopsy (10/1999) | Mild | 0 | 1 | Laparoscopic liver biopsy during surgery for persistent patent ductus venosis |
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ALT, alanine aminotransferase.
