Table 4
Summary of the results from prediction analysis of microarrays (PAM) in cohort A, cohort B and both cohorts combined
| Ulcerative colitis cohort A (R = 8, NR = 16) | Sensitivity | Specificity | Overall accuracy |
| Top 20 genes | 100% (8/8) | 87.5% (14/16) | 91.7% (22/24) |
| Top five genes | 75% (6/8) | 87.5% (14/16) | 83.3% (20/24) |
| The top-ranked gene classifiers of cohort A were used to classify samples in cohort B (R = 12, NR = 10) | Sensitivity in cohort B | Specificity in cohort B | Overall accuracy in cohort B |
| Cohort A top 20 genes | 25% (3/12) | 100% (10/10) | 59.1% (13/22) |
| Cohort A top five genes | 25% (3/12) | 100% (10/10) | 59.1% (13/22) |
| Ulcerative colitis cohort B (R = 12, NR = 10) | Sensitivity | Specificity | Overall accuracy |
| Top 20 genes | 91.7% (11/12) | 80% (8/10) | 86.4% (19/22) |
| Top five genes | 91.7% (11/12) | 90% (9/10) | 90.9% (20/22) |
| The top-ranked gene classifiers of cohort B were used to classify samples in cohort A (R = 8, NR = 16) | Sensitivity in cohort A | Specificity in cohort A | Overall accuracy in cohort A |
| Cohort B top 20 genes | 87.5% (7/8) | 56.3% (9/16) | 66.7% (16/24) |
| Cohort B top five genes | 87.5% (7/8) | 62.5% (10/16) | 70.8% (17/24) |
| Ulcerative colitis cohort A and B (R = 20, NR = 26) | Sensitivity | Specificity | Overall accuracy |
| Top 20 genes | 95% (19/20) | 76.9% (20/26) | 84.8% (39/46) |
| Top five genes | 95% (19/20) | 84.6% (22/26) | 89.1% (41/46) |
-
NR, non-responders; R, responders.
