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Chronic hepatitis C (CHC) remains frequent in dialysis patients.1 Currently, interferon (IFN) monotherapy is the standard of care for dialysis CHC patients.2 In a previous paper published in the journal, we demonstrated that treatment with weekly pegylated IFNα-2a had a significantly higher sustained virological response (SVR) rate than that with thrice weekly standard IFNα-2a in such patients (48% vs 20%, p = 0.02).3 Although dialysis CHC patients responded better to IFN monotherapy than those with normal renal function, the overall SVR rates are far from satisfactory.4 5
Retreatment with pegylated IFN plus ribavirin in ordinary CHC patients who relapsed from prior standard IFN had an SVR rate of 52%.6 Among these patients, the SVR rates for genotype 1 and 2/3 patients were 47% and 63%, respectively. Although ribavirin is contraindicated in dialysis CHC patients for the risk of …
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