Gut 58:586-593 doi:10.1136/gut.2008.162859
  • Recent advances in basic science

Dietary modulation of peroxisome proliferator-activated receptor gamma

  1. R Marion-Letellier1,
  2. P Déchelotte1,
  3. M Iacucci2,
  4. S Ghosh2
  1. 1
    Appareil Digestif Environnement Nutrition (ADEN EA 4311), Institute for Biomedical Research, European Institute for Peptide Research (IFR23), Rouen University and Rouen University Hospital, Rouen, France
  2. 2
    Gastroenterology Section, Imperial College Faculty of Medicine, Hammersmith Hospital Campus, London, UK
  1. Dr R Marion-Letellier, Appareil Digestif Environnement Nutrition (ADEN EA 4311), Faculté de Médecine-Pharmacie, Institut Fédératif de Recherches Multidisciplinaires sur les Peptides (IFR23), 22, boulevard Gambetta, 76183 Rouen cedex, France; marion_rachel{at}
  • Revised 22 September 2008
  • Accepted 14 October 2008
  • Published Online First 18 November 2008


Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor that regulates intestinal inflammation. PPARγ is highly expressed in the colon and can be activated by various dietary ligands. A number of fatty acids such as polyunsaturated fatty acids or eicosanoids are considered as endogenous PPARγ activators. Nevertheless, other nutrients such as glutamine, spicy food or flavonoids are also able to activate PPARγ. As PPARγ plays a key role in bacterial induced inflammation, anti-inflammatory properties of probiotics may be mediated through PPARγ. The aims of the present review are to discuss of the potential roles of dietary compounds in modulating intestinal inflammation through PPARγ.


  • Competing interests: None.