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Authors’ response
  1. M W Lutgens,
  2. B Oldenburg,
  3. F P Vleggaar
  1. University Medical Center Utrecht, Utrecht, The Netherlands
  1. Dr F P Vleggaar University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands; f.vleggaar{at}umcutrecht.nl

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We read with great interest and appreciation the comment by Dr Loffeld. His observation of selection bias towards patients with more severe disease is correct, and indeed was most likely to have been present in our data. We were fully aware of this during the study and therefore commented on it in the Discussion section of our original …

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