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In their recent study, Van den Brande and colleagues (Gut 2007;56:509–17) demonstrated the induction of apoptosis by infliximab in lamina propria T lymphocytes of patients with Crohn’s disease (CD) in situ and showed a correlation between 99mTc-annexin V uptake and and response to infliximab treatment. Interestingly, Nesbitt et al1 reported that the novel antitumour necrosis factor (TNF) compound certolizumab pegol does not induce apoptosis despite its clinical activity. A recent paper by Di Sabatino and colleagues2 reports that the production of tissue inhibitor of metalloproteinases (TIMP)-1 is enhanced in myofibroblasts from patients with CD by infliximab in a mitogen-activated protein kinase (MAPK) p38-dependent manner. This effect was not accompanied by significant induction of …
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