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We read with great interest the article by Roberts and co-authors (Gut 2006;55:1697–703) who reported a case–control study of oesophageal pathology in systemic sclerosis. Their findings and conclusions are an important contribution to the better understanding of the pathomechanisms of scleroderma-related oesophageal dysmotility.
As we have been investigating full-thickness biopsies of the bowel in various forms of intestinal dysmotility for more than two decades we were particularly interested in the changes of the myenteric plexus in their control material. Our interest derives from the paucity of data on the normal enteric nervous system due to the difficulties obtaining bowel tissue from healthy individuals.
The findings of “myenteric plexus-associated lymphocytes” in their control material and …
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