rss
Gut 2009;58:1218-1225 doi:10.1136/gut.2009.177782
  • Inflammatory bowel disease

Plexitis as a predictive factor of early postoperative clinical recurrence in Crohn’s disease

  1. H Sokol1,
  2. V Polin2,
  3. A Lavergne-Slove3,
  4. Y Panis4,
  5. X Treton5,
  6. X Dray2,6,
  7. Y Bouhnik5,
  8. P Valleur2,
  9. P Marteau2,6
  1. 1
    AP-HP, Saint-Antoine Hospital, Gastroenterology and Nutrition Department, Paris, France
  2. 2
    AP-HP, Lariboisière Hospital, Medicosurgical Department of Digestive Diseases, Paris, France
  3. 3
    AP-HP, Lariboisière Hospital, Anatomopathology Department, Paris, France
  4. 4
    AP-HP, Beaujon Hospital, Surgery Department, PMAD, Clichy, France
  5. 5
    AP-HP, Beaujon Hospital, Gastroenterology Department, PMAD, Clichy, France
  6. 6
    Laboratoire de Biologie EA 3199, CNAM, Paris, France
  1. Correspondence to Professor P Marteau, Medicosurgical Department of Digestive Diseases, Lariboisière Hospital, AP-HP, 2 rue Ambroise Paré, 75010 Paris, France; philippe.marteau{at}lrb.aphp.fr
  • Revised 12 March 2009
  • Accepted 31 March 2009
  • Published Online First 21 July 2009

Abstract

Background and aims: A previous study suggested that the presence of myenteric plexitis in the proximal resection margins could be predictive of early endoscopic recurrence after ileocolonic or ileal resection for Crohn’s disease (CD). The aim of the present study was to assess the predictive value of plexitis for early clinical CD recurrence.

Methods: All consecutive patients with ileocolonic or ileal resection for active CD in Lariboisière Hospital (Paris) between 1995 and 2006 were included. Clinical, surgical, histological and follow-up data were extracted from medical charts. Early clinical recurrence was defined as the reappearance of CD clinical manifestations requiring a specific treatment within 2 years postsurgery. The proximal resection margin was analysed using haematein eosin saffron (HES) staining and immunochemistry targeting mastocytes (anti-CD117 antibody) and lymphocytes (anti-CD3 antibody). Eosinophils were detected by HES staining. Ten cases of ileocolonic resections for caecal carcinoma served as controls.

Results: Data were available from 171 postoperative follow-up periods in 164 patients with CD. Early clinical recurrence of CD occurred in 28.1%. In multivariate analysis, factors associated with postoperative recurrence were active smoking (hazard ratio (HR) = 1.94; 95% CI 1.06 to 3.60; p = 0.033), submucosal plexitis with ≥3 mastocytes (HR = 1.87; 95% CI 1.00 to 3.46; p = 0.048) and a disease-free resection margin <5 cm (HR = 0.52; 95% CI 0.27 to 1.02; p = 0.059).

Conclusions: Submucosal plexitis is associated with early clinical recurrence and could be taken into account in studies searching for new treatment strategies in the immediate postoperative period.

Footnotes

  • Competing interests None.

Relevant Article

This Article

  1. Abstract
  2. Full text
  3. PDF
  4. All Versions of this Article:
    1. gut.2009.177782v1
    2. 58/9/1218 most recent

Social bookmarking

Latest from Gut Education

Latest from Gut Education

Register for free content


Free sample
 This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of Gut.
View free sample issue >>

Free archive
The full back archive is now available for Gut. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006, back to volume 1 issue 1.
Register to access the free archive >>

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.