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We welcome the letter from Dr Jubb1 in reply to our recently published study.2
It was clearly laid out that our endpoints included not only response or time to progression but also overall survival (OS), which is the criterion standard of clinical endpoints. Whereas progression-free survival has been validated as a surrogate endpoint in metastatic colorectal cancer (mCRC) for first-line chemotherapy, tumour response and time to progression were not appropriate surrogate endpoints.3 Furthermore, recent articles underlined that validation of surrogacy is dependent upon both the setting and the studied treatment.4 We therefore fully agree that the surrogacy of progression-free survival should be validated in mCRC treated by chemotherapy + bevacizumab before its use as primary endpoint. Therefore, we investigated in the article the impact of …
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