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Metabolic syndrome and chronic hepatitis B: is the evidence enough?
  1. Henry Lik-Yuen Chan,
  2. Grace Lai-Hung Wong,
  3. Vincent Wai-Sun Wong
  1. Institute of Digestive Disease and Department of Medicine and Therapeutics, The Chinese University of Hong Kong; Hong Kong SAR, China
  1. Correspondence to Dr Henry Lik-Yuen Chan, Department of Medicine and Therapeutics, 9/F Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, Hong Kong, China; hlychan{at}

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We appreciated the interest and comment of Li and colleagues on our recent publication.1 We would like to acknowledge the results from the Taiwanese longitudinal studies concerning the effect of fatty liver, obesity and type 2 diabetes on the risk of liver cirrhosis and hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients. This evidence echoed the conclusion of the present study that metabolic syndrome increased the risk of liver cirrhosis in CHB.

In the present cross-sectional study, the causal …

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