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Insulin resistance, viral load and response to peginterferon and ribavirin in patients with chronic hepatitis C virus infection
  1. Chia-Yen Dai1,2,3,
  2. Jee-Fu Huang1,2,4,
  3. Ming-Yen Hsieh1,
  4. Wan-Long Chuang1,2,
  5. Ming-Lung Yu1,2
  1. 1Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
  2. 2Faculty of Internal Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
  3. 3Department of Occupational and Environmental Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
  4. 4Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan
  1. Correspondence to Dr Ming-Lung Yu, Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, No. 100, Tzyou 1st Rd, Kaohsiung 807, Taiwan; d820195{at}gmail.com

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We read the article by Moucari et al in Gut recently1 with great interest. The authors concluded that insulin resistance (IR) is correlated independently with serum hepatitis C virus (HCV)-RNA and frequently encountered in patients with HCV genotype 4 (HCV-4) infection. Also IR is a major predictor of response to peginterferon and ribavirin in 108 HCV-4 patients receiving a 48-week course of peginterferon plus ribavirin.

In our previous study we enrolled 330 Taiwanese patients with chronic hepatitis C (CHC) (150 HCV genotype 1 (HCV-1) and 180 genotype non 1 (HCV-non 1) to evaluate the association between homeostasis model assessment of IR (HOMA-IR) and response to therapy.2 We checked the association between HOMA-IR and serum HCV-RNA level. The …

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