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- insulin resistance
- hepatitis C virus
- hepatitis C virus genotype 4
- homeostasis model assessment of IR
We read the article by Moucari et al in Gut recently1 with great interest. The authors concluded that insulin resistance (IR) is correlated independently with serum hepatitis C virus (HCV)-RNA and frequently encountered in patients with HCV genotype 4 (HCV-4) infection. Also IR is a major predictor of response to peginterferon and ribavirin in 108 HCV-4 patients receiving a 48-week course of peginterferon plus ribavirin.
In our previous study we enrolled 330 Taiwanese patients with chronic hepatitis C (CHC) (150 HCV genotype 1 (HCV-1) and 180 genotype non 1 (HCV-non 1) to evaluate the association between homeostasis model assessment of IR (HOMA-IR) and response to therapy.2 We checked the association between HOMA-IR and serum HCV-RNA level. The …
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