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The relative role of viral load and metabolic factors in the risk of cirrhosis in chronic hepatitis B
  1. W J Jeng,
  2. C M Chu
  1. Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
  1. Correspondence to Dr Chia-Ming Chu, Liver Research Unit, Chang Gung Memorial Hospital, 199, Tung Hwa North Road, Taipei 10591, Taiwan; chiamingchu{at}

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We read with great interest the recent article by Wong et al highlighting the increased risk of liver cirrhosis in chronic hepatitis B with metabolic syndrome.1 In this large series cross-sectional study the authors have demonstrated many factors significantly associated with increased risk of cirrhosis in univariate analysis, including metabolic syndrome and serum levels of hepatitis B virus (HBV) DNA. However, in multivariate logistic regression analysis serum levels of HBV DNA (cut-off value of 102 copies/ml) did not have a consistent effect on the risk of cirrhosis while metabolic syndrome remained a significant risk factor. These data seemed to …

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  • PostScript
    Grace Lai-Hung Wong Vincent Wai-Sun Wong Henry Lik-Yuen Chan