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The interesting study by Tuin et al1 in a recent issue of Gut uncovers a hitherto unrecognised protective role of alkaline phosphatase (AP) in intestinal inflammation. These authors measured AP activity (including lipopolysaccharide (LPS) as a substrate) and mRNA level of the intestinal isoform (IAP) in inflamed and non-inflamed mucosa of patients with inflammatory bowel disease. IAP expression and AP activity were virtually non-existent in the colon when compared to the ileum.
These researchers follow up on a recent paper by Richard Hodin's group2 which describes …
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