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It may not be intestinal, but tissue non-specific alkaline phosphatase
  1. Olga Martínez-Augustin1,
  2. Rocío López-Posadas1,
  3. Raquel González1,
  4. Isabel Ballester2,
  5. María Dolores Suárez1,
  6. Antonio Zarzuelo1,
  7. Fermín Sánchez de Medina1
  1. 1Departments of Biochemistry and Molecular Biology II and Pharmacology, CIBERehd, School of Pharmacy, University of Granada, Granada, Spain
  2. 2Gastrointestinal Unit, Massachusetts General Hospital, Boston, USA
  1. Correspondence to Dr Fermin Sanchez de Medina, University of Granada, School of Pharmacy, Campus de Cartuja S/N, Granada 18071, Spain; fsanchez{at}

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The interesting study by Tuin et al1 in a recent issue of Gut uncovers a hitherto unrecognised protective role of alkaline phosphatase (AP) in intestinal inflammation. These authors measured AP activity (including lipopolysaccharide (LPS) as a substrate) and mRNA level of the intestinal isoform (IAP) in inflamed and non-inflamed mucosa of patients with inflammatory bowel disease. IAP expression and AP activity were virtually non-existent in the colon when compared to the ileum.

These researchers follow up on a recent paper by Richard Hodin's group2 which describes …

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  • PostScript
    Klaas Poelstra Gerard Dijkstra Annemarie Tuin