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As mentioned by Martinez-Augustin et al, we found reduced levels for intestinal alkaline phosphatase (AP) mRNA in rats with dextran sulfate sodium (DSS)-induced colitis and in patients with ulcerative colitis.1 In the same paper we show a reduced enzyme activity along the intestinal epithelium in sections from rats with DSS-induced colitis (figure 6K of Tuin et al1). There is no contradiction in this. …
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